Clocks in the Vasculature Essay Example | Topics and Well Written Essays - 1000 words

Clocks in the Vasculature - Essay Example An example is mammalian sleep rhythm or hunger, and its is now well known that there is a light-controlled master clock in the brain that controls these activities. Now the research is exploring the molecular mechanisms of these clocks in the peripheral tissues, which have been postulated to work through nutrient availability, although the exact mechanism is not known. heart which is essentially vascular tissue. This activity physiologically is autonomous, originating in the neurocardiac muscles of the heart and in health, occurs 72 times per minute in a regular fashion. In most and usual cases, human beings cannot control the frequency of these beats on their own. However, several neurophysiological conditions can cause change in this pattern and there is established roles of emotion, feelings, strenuous activities, stress in destabilizing this clock either to a higher or a lower rate, and there are physiological systems that tends to bring back these abnormal rates to normal through neural and humoral mechanisms. Small molecules interact with molecular hormone receptors module circadian rhythm. Catecholamines, vasoactive hormones, such as vasopressin and angiotensin interact with positive circadian regulators both centrally and at the peripheral vascular tissues to express circadian variations in heart rates, blood pressure, and vascular resistance (Harris, 2009). Genetic Mechanism Curtis et al. (2004) indicated the molecular mechanism of this clock. This occurs through pacemaker rhythms generated and sustained through positive and negative feedback loops. These in turn are mediated through transcriptional regulation at the genetic level (Curtis et al. 2004). Molecular Mechanism The drivers of this biological and molecular rhythmicity are transcriptional activation of of Per and Cry genes. These occur through transcriptional activation of feedback loop by heterodimeric bHLH-PAS proteins. It has been shown that these trascriptional coactivators and histone acetyltransferase initiate the key events in molecular rhythmicity. These, p300/CBP, PCAF, and ACTR, react with bHLH-PAS proteins, CLOCK and NPSA2, to lead to positive gene expression (Ko and Takahashi, 2006). Link to Vasculature The negative feedback loop is mediated by Cry2 mediated repression of NPAS2:BMAL1 through overexpression of p300. This leads to a circadian and time-dependent association with NPAS2 in the vasculature, which is timed in such a manner that it will precede the peak expression of the target genes (Westgate et al., 2008). Therefore, at the molecular level this is essentially a histone H3 acetylation. It has been correlated with the cyclical expression of the mRNAs

Management Information System Case Study Example | Topics and Well Written Essays - 1500 words

Management Information System - Case Study Example It becomes more personalised and gives the customer more accurate information. Making the whole service contract process friendlier and quicker is one way to help gain more service customers because it should result in the sale of more of these contracts. The company wants to automate its entire application process to speed up everything for both APCO and its customers and to eliminate much of the reliance on paper documents. Extract the information as easily as possible, without a lot of IT over- head Use the Internet as a Channel to achieve the above goals Information systems and business strategy now align with each other to deliver Strategic information systems. Such systems deliver Computer system at any level of an organisation; changes goals, operations, products, services, or environmental relationships and helps organisation gain a competitive advantage The Internet is changing the role of information systems in organisations. The Internet is capable of dramatically reducing transaction and agency costs. Businesses are rapidly rebuilding some key business processes based on Internet technology. Internet technology becoming a key component of IT infrastructure. The need of the hour was to have a new Sales Management system and a Claims Processing System that would allow APCO to manage sales more efficiently and process claims with limited overheads and maximum efficiency and modify business processes to align to the new information processing systems. The systems need to use the Internet as a delivery channel to deliver maximum benefits to the new business processes structured around this channel. Both these above systems are Operational level systems. As a first step APCO wants to introduce a comprehensive electronic document- management (or... The Internet is changing the role of information systems in organisations. The Internet is capable of dramatically reducing transaction and agency costs. Businesses are rapidly rebuilding some key business processes based on Internet technology. Internet technology becoming a key component of IT infrastructure. The need of the hour was to have a new Sales Management system and a Claims Processing System that would allow APCO to manage sales more efficiently and process claims with limited overheads and maximum efficiency and modify business processes to align to the new information processing systems. The systems need to use the Internet as a delivery channel to deliver maximum benefits to the new business processes structured around this channel. Both these above systems are Operational level systems. As a first step APCO wants to introduce a comprehensive electronic document- management (or content-management) system.